Basic Information
VIS ID
TVIS44016695
Fusion event
HTLV-1-LAMTOR4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99740379/100142756 (Hg38)
End
99740379/100142756 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
LAMTOR4
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-766-3p ; hsa-mir-424-5p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-10525/Upstream/48682; hsa-mir-10399/Downstream/13849;
Nearest TSS
ENST00000635602/Upstream/11792; ENST00000494136/Downstream/6151;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/14571, chr7-CpG: 32/Downstream/5874
Nearby gene
LAMTOR4(No orient, 6151)
Upstream sequence
gctgcattgagctgagattgcgacactgcactccagcctgggtaacaaggtgagaccccgtgtccaaaaaacaagagagaTAGAGTGAACATGGGTGAAA
Downstream sequence
GTCCTTCAGCAACTGGGAAGGTAAACTTTAGAGAAGCATCTTCTGCTGTTTGTTGAGACTCTAATCCATGGGCATTCACTGAAAGGCAGAGATGTATTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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