Basic Information
VIS ID
TVIS44016697
Fusion event
HTLV-1-ALKBH4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
102100679/102460232 (Hg38)
End
102100679/102460232 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
ALKBH4
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-193b-3p ; hsa-mir-92a-3p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-153-5p ; hsa-mir-548o-3p ; hsa-mir-1323 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-607 ; hsa-mir-5696 ; hsa-mir-4729 ; hsa-mir-3662 ; hsa-mir-6883-3p ; hsa-mir-3671 ; hsa-mir-676-5p ; hsa-mir-1266-3p ; hsa-mir-4762-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-6732-3p
Nearest miRNA
hsa-mir-10525/Upstream/54377; hsa-mir-10399/Downstream/5510;
Nearest TSS
ENST00000635602/Upstream/23933; ENST00000626402/Downstream/4625;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2295, chr7-CpG: 83/Downstream/4444
Upstream sequence
gacagagtgagactcaaaaaaaaaaaaaaagtttaaataaaaattagccgggtgtggcagagcgcacttgtcatttcagctactcaggaggctgaggcgg
Downstream sequence
gaggatcatttgagcccaggaggttgaggctacagtgagccatggtcgcgctactgcactccagcctggacaacaaagcaagaccctgtctcaaaaaaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate