Basic Information
VIS ID
TVIS44016703
Fusion event
HTLV-1-MET integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
116326269/116686215 (Hg38)
End
116326269/116686215 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7G
Target gene
MET
miRNAs that regulate target gene
hsa-mir-206 ; hsa-mir-34c-5p ; hsa-mir-34b-5p ; hsa-mir-34a-5p ; hsa-mir-1-3p ; hsa-mir-199a-3p ; hsa-mir-23b-3p ; hsa-mir-34b-3p ; hsa-mir-562 ; hsa-mir-30a-5p ; hsa-mir-340-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-198 ; hsa-mir-130a-3p ; hsa-mir-133b ; hsa-mir-31-5p ; hsa-mir-1303 ; hsa-mir-320a ; hsa-mir-27a-3p ; hsa-mir-137 ; hsa-mir-410-3p ; hsa-mir-148a-3p ; hsa-mir-449c-5p ; hsa-mir-409-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-7515 ; hsa-mir-218-5p ; hsa-mir-433-3p ; hsa-mir-139-5p ; hsa-mir-27b-3p ; hsa-mir-34a-3p ; hsa-mir-1-5p ; hsa-mir-144-5p ; hsa-mir-1257 ; hsa-mir-1262 ; hsa-mir-425-5p ; hsa-mir-4506 ; hsa-mir-4701-3p ; hsa-mir-545-5p ; hsa-mir-6736-5p ; hsa-mir-802
Nearest miRNA
hsa-mir-10525/Upstream/2032760; hsa-mir-10399/Downstream/333996;
Nearest TSS
ENST00000635602/Upstream/13810; ENST00000495962/Downstream/12870;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13783, chr7-CpG: 69/Downstream/176158
Nearest cancer related gene
MET(OG, No orient, 0)
Upstream sequence
caacataatccccccttgttcaacaccctgcaatgactccccatttcactccaataaaaacctgaatctcccaggggcctacaaggccttacatgctctg
Downstream sequence
cttctttgtccttttgatctcagctcccggtcaacaaagtccaggcttactggcccccttgctgtgcttcagacacaccaggcacatttagttcttcctt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate