Basic Information
VIS ID
TVIS44016720
Fusion event
HTLV-1-MKLN1-AS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
131005497/131320738 (Hg38)
End
131005497/131320738 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA7H
Target gene
MKLN1-AS
Nearest miRNA
hsa-mir-10525/Upstream/443199; hsa-mir-10399/Downstream/1714122;
Nearest TSS
ENST00000635602/Upstream/35676; ENST00000446815/Downstream/7108;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/212724, chr7-CpG: 74/Downstream/6963
Upstream sequence
ggcaacctacagaatgagagaaaaattttgcaatctacccatgtgtcaaaggtctaatatccagaatctacaaggaacttaaacaaattttcaagaaaaa
Downstream sequence
aaacaaacaaccccaacaaaaagtgggcaaagaatatgaacagacacttccagaagaagagattgatgtggccaacaaacatatgaaaaatagctcatca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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