Basic Information
VIS ID
TVIS44016725
Fusion event
HTLV-1-AKR1B10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
134223143/134538391 (Hg38)
End
134223143/134538391 (Hg38)
Orient
+
Location type
Intronic
Target gene
AKR1B10
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-145-5p ; hsa-mir-98-5p ; hsa-mir-3611 ; hsa-mir-943 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-325 ; hsa-mir-628-3p ; hsa-mir-648 ; hsa-mir-1244 ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-142-3p ; hsa-mir-6878-5p ; hsa-mir-922 ; hsa-mir-3919 ; hsa-mir-6838-5p ; hsa-mir-6760-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-3123 ; hsa-mir-6864-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-3940-3p
Nearest miRNA
hsa-mir-10525/Upstream/1247403; hsa-mir-10399/Downstream/668603;
Nearest TSS
ENST00000635602/Upstream/778; ENST00000467156/Downstream/10745;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/79080, chr7-CpG: 63/Downstream/447977
Upstream sequence
GGTCGGCCCTGGTATTCCTCAGTGGAGTGGGGGACAGGCAGACCTTCTCACTAGGCTTCTCACCTCATCGCTGCATTGTCTTTTGCCCCCTCCCTTCCCA
Downstream sequence
CCACCCTATCATTTTCCAGCCCAGGGAGCTAGGGTCAGTAGAGCTGAGATGAATGACCCATGGGCTAAGGACATCCTGGGGGCAGTGCCTGGTAAAGCCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate