Basic Information
VIS ID
TVIS44016732
Fusion event
HTLV-1-ADCK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
140394664/140694864 (Hg38)
End
140394664/140694864 (Hg38)
Orient
+
Location type
UTR3
Target gene
ADCK2
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-484 ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-10399/Upstream/1650707; hsa-mir-11400/Downstream/1779663;
Nearest TSS
ENST00000635602/Upstream/4087; ENST00000462847/Downstream/1807;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/21221, chr7-CpG: 95/Downstream/1750
Upstream sequence
AGGCCCTTCCTCCTCACGGGCCCAGTGTGCCCCCCGTGATGGGGCAGTGGCCTCTGTGGGCCCTTGTCAAGAGCTGGAGGCCACTCCCAAGAGCCTCTCC
Downstream sequence
TATGGCAGCTGGGACGTTTTAAAATTGGGACACCAATTTCAAATGTAACCCTCCAGTGGTGGAAGGCACACCATGGCTTCCTCTGCTTGGTTTGAGGGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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