Basic Information
VIS ID
TVIS44016735
Fusion event
HTLV-1-FAM131B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
143056638/143359545 (Hg38)
End
143056638/143359545 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM131B
miRNAs that regulate target gene
hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-3190-3p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-3202 ; hsa-mir-6836-5p ; hsa-mir-4533 ; hsa-mir-6132 ; hsa-mir-605-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3714 ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-3137 ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-338-3p ; hsa-mir-4530 ; hsa-mir-3614-3p
Nearest miRNA
hsa-mir-10399/Upstream/884942; hsa-mir-153-2/Downstream/23141;
Nearest TSS
ENST00000635602/Upstream/38071; ENST00000609674/Downstream/212;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13771, chr7-CpG: 117/Downstream/2202
Upstream sequence
CAGAGGAATAAGAAGGTACGGGCGTGCTTTATACATGGAGGAGGTTCATGGTTTCCAGGAAAAAGCATTCGAGCTAGGGCAGATGATAAGAAAAGCTACT
Downstream sequence
ATACCCAAGAGTCCCAAGGAGGGATATATCCCCAGTGCTCTGGAAAACTGGGGCACAGGTTGAGAACGTGAGTGCTCACAGTGCCTATTGGAGCCAGGGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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