Basic Information
VIS ID
TVIS44016739
Fusion event
HTLV-1-INTS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
1538727/1499091 (Hg38)
End
1538727/1499091 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA7B
Target gene
INTS1
miRNAs that regulate target gene
hsa-mir-877-5p ; hsa-mir-769-3p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-let-7b-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-339/Upstream/476065; hsa-mir-10399/Downstream/345089;
Nearest TSS
ENST00000635602/Upstream/2879; ENST00000406174/Downstream/2188;
Nearest CpG islands
chr7-CpG: 51/Target, None/Upstream, None/Downstream
Nearest cancer related gene
INTS1(OG, No orient, 0)
Upstream sequence
ACATCTCCAGCTTCTGCACCGCCAGCAGCCGCACCTCCTTATAGCCGCAGGTGGAGGTGAGGAGCCGCAGGAGGTTCCTGGAGACGTTGTCGATGGGCTG
Downstream sequence
GCGCCGGTTCAGCTGGTCCCGCAGCATGTCCAGGACATACTCCTCCACGCTCTCCGCGAGCTCTTCGTACCTAGGCCAGAGGAGGGAGCGAGGAGGGAGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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