Basic Information
VIS ID
TVIS44016744
Fusion event
HTLV-1-AGMO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
15506072/15466447 (Hg38)
End
15506072/15466447 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGMO
miRNAs that regulate target gene
hsa-mir-5698 ; hsa-mir-6738-3p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-143-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-6499-3p ; hsa-mir-6777-3p ; hsa-mir-483-3p ; hsa-mir-3145-5p ; hsa-mir-3680-5p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p
Nearest miRNA
hsa-mir-339/Upstream/8399402; hsa-mir-10399/Downstream/2660773;
Nearest TSS
ENST00000635602/Upstream/69853; ENST00000451240/Downstream/95568;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1474859, chr7-CpG: 17/Downstream/933050
Upstream sequence
AAGCATTTTTTTGGTCTAGTGGAGAAGACAAGCATTAATTTAATGATATAATGTAGTTAATGTtatatgcaacatatcaccgtgagcactttactgctat
Downstream sequence
taacacatctaattttcacaacttcctgaagtaggtagcattaatggctcatgttataggtgaagaaaagctgagaaagattaaggaacttgcctagggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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