Basic Information
VIS ID
TVIS44016745
Fusion event
HTLV-1-MEOX2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
15725292/15685667 (Hg38)
End
15725292/15685667 (Hg38)
Orient
+
Location type
Intronic
Target gene
MEOX2
miRNAs that regulate target gene
hsa-mir-301a-3p ; hsa-mir-130a-3p ; hsa-mir-335-5p ; hsa-mir-221-3p ; hsa-mir-320a ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4684-5p ; hsa-mir-4742-3p ; hsa-mir-138-1-3p ; hsa-mir-1183
Nearest miRNA
hsa-mir-339/Upstream/8618622; hsa-mir-10399/Downstream/2441553;
Nearest TSS
ENST00000635602/Upstream/17720; ENST00000442176/Downstream/1145;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1694079, chr7-CpG: 17/Downstream/713830
Upstream sequence
CAGCGCTGGGATGGAAGGTCACGCTTCACAATCGATTTCACAGCCACTTGTCCTTTTTTATCAACCTTCTGGTAAACTAGTTTAGGACTTTGGAGGGCTT
Downstream sequence
AGAGCTGCTGGCTGTATACGCATTGCTCTCGAATAAACACGTGTCCCCAAATATCAGGACCAAAGCTTCACCGCCGAATTTGGCCGCAGGAAGCCACAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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