Basic Information
VIS ID
TVIS44016749
Fusion event
HTLV-1-PTPRN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
158136307/158343615 (Hg38)
End
158136307/158343615 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
PTPRN2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-539-5p ; hsa-mir-7110-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5680 ; hsa-mir-4311 ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6715b-3p ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-1228-3p ; hsa-mir-342-3p
Nearest miRNA
hsa-mir-10399/Upstream/769193; hsa-mir-5707/Downstream/189103;
Nearest TSS
ENST00000635602/Upstream/138338; ENST00000448698/Downstream/193880;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/25426, chr7-CpG: 18/Downstream/8273
Upstream sequence
gaagtagcagatgatccgacagccccatttgattttacacccaatacctgcaagcagggctcgcgcagaggctcaggcagccatgctggtggcaCATGGG
Downstream sequence
CTGTCGCGACTGCTCCCGGTGGAATCAGCCCCATTTCTGATTTTACACCCAACACCTGCAAGCAGAGCTCGCGCAGAGGCTCAGGCAGCCATGCTCGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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