Basic Information
VIS ID
TVIS44016779
Fusion event
HTLV-1-GPR141 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
37757190/37717588 (Hg38)
End
37757190/37717588 (Hg38)
Orient
-
Location type
Intronic
Target gene
GPR141
miRNAs that regulate target gene
hsa-mir-552-5p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-4775 ; hsa-mir-410-3p ; hsa-mir-590-3p ; hsa-mir-1277-5p ; hsa-mir-493-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-3613-5p ; hsa-mir-4740-3p ; hsa-mir-6729-3p ; hsa-mir-205-3p ; hsa-mir-6871-5p ; hsa-mir-5683
Nearest miRNA
hsa-mir-1183/Upstream/798156; hsa-mir-10399/Downstream/5433307;
Nearest TSS
ENST00000635602/Upstream/33716; ENST00000334425/Downstream/22806;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/268519, chr7-CpG: 82/Downstream/198432
Nearby gene
GPR141(+22806) ;
Upstream sequence
TTCATTAACAAACGTTTCCATATCAGtgcctgccttttgtggctcatgctgtccatccctgacattttctgccccctctttctttctctcaccccccttg
Downstream sequence
ttgtgtactaaatcctttctgcctttaagtgtcactccaaaaccagcttcctgcatgaagccttctcagattcccccttctcccagtttggcttgttctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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