Basic Information
VIS ID
TVIS44016788
Fusion event
HTLV-1-POLR2J4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
44014757/43975158 (Hg38)
End
44014757/43975158 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA7D
Target gene
POLR2J4
Nearest miRNA
hsa-mir-1183/Upstream/824164; hsa-mir-10399/Downstream/76608;
Nearest TSS
ENST00000635602/Upstream/26556; ENST00000258704/Downstream/25731;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48357, chr7-CpG: 45/Downstream/43851
Upstream sequence
TGGTCAGAGGGGTCGAGGCAGGGCCCTGGGCAGCGGGTGGACAGGCTCCGTGATCAGAGGGACCGTCACCCAGCCCGCCCTTGGCCGTCAGCCCAGACCC
Downstream sequence
AGGTTCCTCTCTTCCCAGAAGTTCATCCCCCTAAATGGACTTACGTGCTTAGCTCTCATTAACATTCTGAACCTTCCAGAAAGGGAGTGGAAATATCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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