Basic Information
VIS ID
TVIS44016809
Fusion event
HTLV-1-TNRC18P2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
63041038/63580660 (Hg38)
End
63041038/63580660 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
TNRC18P2
miRNAs that regulate target gene
hsa-mir-620 ; hsa-mir-1270 ; hsa-mir-548au-3p ; hsa-mir-4683 ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-34a-5p ; hsa-mir-4632-3p ; hsa-mir-7109-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-1911-5p ; hsa-mir-637 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-3614-5p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-937-3p ; hsa-mir-6742-5p ; hsa-mir-410-3p
Nearest miRNA
hsa-mir-1183/Upstream/6175570; hsa-mir-10399/Downstream/40430;
Nearest TSS
ENST00000635602/Upstream/186383; ENST00000450544/Downstream/312818;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/8008, chr7-CpG: 18/Downstream/90
Nearby gene
MIR4283-2(+40430) ;
Upstream sequence
GTAGAGCACACCAGGCTGGCACAGTCCAGATCCTGAGAGAGGCCAGCACGCTCTCTCACCCCTTCCCACTGTGGCTCCTGCCATGGAGCAGCCGTGCCCA
Downstream sequence
GCCCCTGGGAGGGTTCACCTGGTACTCCCTCAAAGTGCCCAGGGCCTCCCCGTCAGCTCTGAGCCCACTCATGCCCCTGCCCTGTGCCTTCGGGGGAAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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