Basic Information
VIS ID
TVIS44016818
Fusion event
HTLV-1-CALN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
71492477/72027492 (Hg38)
End
71492477/72027492 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
CALN1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-675-5p ; hsa-mir-4635 ; hsa-mir-6849-3p ; hsa-mir-596 ; hsa-mir-634 ; hsa-mir-4520-2-3p ; hsa-mir-3692-3p ; hsa-mir-4520-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-3614-5p ; hsa-mir-890 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-7153-3p ; hsa-mir-137
Nearest miRNA
hsa-mir-1183/Upstream/719722; hsa-mir-10399/Downstream/670411;
Nearest TSS
ENST00000635602/Upstream/216997; ENST00000434423/Downstream/309503;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/894096, chr7-CpG: 187/Downstream/308280
Upstream sequence
AAGGACACGAATCTATTTTTGCAAAGACATCATGAGggccaggtgcagtggctcatgcctgtaatcctagcactttgggaggccgaggagggtggatcac
Downstream sequence
ttaaggccaggagtttgagaccagcttgggcaacatggtgaaaccccatctctactaaaaatacaaaaattagccaggtgtggtggcgggcacctgtagt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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