Basic Information
VIS ID
TVIS44016831
Fusion event
HTLV-1-CACNA2D1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
81691956/82062640 (Hg38)
End
81691956/82062640 (Hg38)
Orient
-
Location type
Intronic
Target gene
CACNA2D1
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-1-3p ; hsa-mir-4642 ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4446-5p ; hsa-mir-6814-5p
Nearest miRNA
hsa-mir-10525/Upstream/6147371; hsa-mir-10399/Downstream/10141375;
Nearest TSS
ENST00000635602/Upstream/24405; ENST00000430696/Downstream/22196;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/451248, chr7-CpG: 161/Downstream/380065
Upstream sequence
tgttaaggtctagtttacctaatacatttgaattatctttgagatcaggtactatgtctttttttttttttaatatactttaagttttagggtacatgtg
Downstream sequence
cacaacgtgcaggtttgttacatacgtatacatgtgccatgttggtgtgttgcacccagtaacttgtcatttacattaggtatatctccttttttttttt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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