Basic Information
VIS ID
TVIS44016835
Fusion event
HTLV-1-ADAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
944056/904419 (Hg38)
End
944056/904419 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
ADAP1
miRNAs that regulate target gene
hsa-mir-8070 ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-4687-3p ; hsa-mir-7974 ; hsa-mir-4679 ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-224-5p ; hsa-mir-5680
Nearest miRNA
hsa-mir-10399/Downstream/118514;
Nearest TSS
ENST00000635602/Upstream/3020; ENST00000462453/Downstream/658;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/164, chr7-CpG: 29/Downstream/3307
Upstream sequence
CTCAAGGGAGCAGGAAGggcagaccctgtgggtgctggcggcgcacctgctgtgctgtgtggctttgggcaagttacttaagcgctctgagccttggcct
Downstream sequence
cccggtctgtaagcagaaggtaacagcacctccctcccaggagtgatggggacctcaacgacactgtgcaggtggcacttgacaTCAGACACTGCACCTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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