Basic Information
VIS ID
TVIS44016838
Fusion event
HTLV-1-VPS50 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
92901668/93272356 (Hg38)
End
92901668/93272356 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS50
miRNAs that regulate target gene
hsa-mir-127-5p ; hsa-mir-4650-3p ; hsa-mir-3132 ; hsa-mir-197-5p ; hsa-mir-5189-3p ; hsa-mir-4257 ; hsa-mir-6755-5p ; hsa-mir-6847-5p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-335-3p ; hsa-mir-4668-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-548z ; hsa-mir-3613-3p ; hsa-mir-548h-3p ; hsa-mir-548bb-3p ; hsa-mir-548d-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10525/Upstream/1068258; hsa-mir-10399/Downstream/210404;
Nearest TSS
ENST00000635602/Upstream/1290; ENST00000485140/Downstream/3486;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/228654, chr7-CpG: 28/Downstream/302417
Upstream sequence
TGTTTTATTGTTCTCCAGTAGTCCCACAAATTCAGTTTATATAAGATTTTAGCAGATGCTTGAGGAAACATTAAGTAGTAGTAAGAGTAAGATTCATTAC
Downstream sequence
AAAACTATTATTTTGTTTCCTGTAAAACACTAGGCATGGGTTTTAAGGCATAGAAATTCACATGTTAATATCTTGGTAAACTTGATTATAGTTGCTAATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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