Basic Information
VIS ID
TVIS44016840
Fusion event
HTLV-1-CASD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
94162152/94532840 (Hg38)
End
94162152/94532840 (Hg38)
Orient
-
Location type
Intronic
Target gene
CASD1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-140-5p ; hsa-mir-452-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-4789-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-587 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p
Nearest miRNA
hsa-mir-10525/Upstream/815835; hsa-mir-10399/Downstream/1686822;
Nearest TSS
ENST00000635602/Upstream/22769; ENST00000471944/Downstream/18893;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/22203, chr7-CpG: 112/Downstream/122706
Upstream sequence
ATTTTGTTAAATATGCATTGGATTTCACTTTCCCAGAAGATTGTTTTGGCACTGACCTTGTATTTTATTTAACACTTACACTGTGTACCCTGTAGGCTTC
Downstream sequence
CATGATTACCTTTTAATTGACTGACATAATACACTAGAGCTTTACTCTAAGCATTTTACTCAGAGTTCAGAATATTAGGTCGTGTTAGATTTCAGTGGTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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