Basic Information
VIS ID
TVIS44016857
Fusion event
HTLV-1-EIF3E integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
109229044/108216815 (Hg38)
End
109229044/108216815 (Hg38)
Orient
+
Location type
Intronic
Target gene
EIF3E
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-29a-3p ; hsa-mir-218-5p ; hsa-mir-335-3p ; hsa-mir-452-3p
Nearest miRNA
hsa-mir-12123/Upstream/3732350; hsa-mir-10400/Downstream/4426678;
Nearest TSS
ENST00000518652/Upstream/13469; ENST00000520037/Downstream/9385;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/133194, chr8-CpG: 43/Downstream/31482
Nearest cancer related gene
EIF3E(OG, No orient, 0)
Upstream sequence
AAAGTCTCATCCTAGAAGCATTCTGAAAGCTTTCAAATTCCTCTACTACCAAAAGTCTCCCTTGGTCAATAAACAGTAATAAACTTCCCCAATCATAAGG
Downstream sequence
GTATTCATTCCCTACTGAATGACAATAACTTCTTTGTATTTAATACACTCTTAAATAAATATTTAAGTTATATTTCTAATCTACGGGTTTTGCTGACAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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