Basic Information
VIS ID
TVIS44016868
Fusion event
HTLV-1-SNTB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.12
Reference genome
GRCh37/hg19
Start
121751692/120739452 (Hg38)
End
121751692/120739452 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
SNTB1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-24-3p ; hsa-mir-5011-5p ; hsa-mir-218-5p ; hsa-mir-510-3p ; hsa-mir-3606-5p ; hsa-mir-1825 ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-8062 ; hsa-mir-1277-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p
Nearest miRNA
hsa-mir-12123/Upstream/1414187; hsa-mir-10400/Downstream/2476336;
Nearest TSS
ENST00000518652/Upstream/45544; ENST00000509350/Downstream/21801;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/294035, chr8-CpG: 121/Downstream/71723
Upstream sequence
TAGCCTAATGAGAAGTGAGGACTTCCAACAATGGGGGTTGTTCTCAGACAATGGCATTCAGTCCTTTTCAAACACAAAGAGGTGTTTTTGTCAAAAAAGG
Downstream sequence
GAATTTCCCAAGAAACCTAAGTTTTTCTGTACAAGCATTTAGGAACTCAAAGTGGAGAGCAGCCCATGCAGGATCCTAATAAACTAAAATTATCTTTTGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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