Basic Information
VIS ID
TVIS44016870
Fusion event
HTLV-1-WDYHV1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
124454046/123441806 (Hg38)
End
124454046/123441806 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA8C ; FRA8E
Target gene
WDYHV1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-192-3p ; hsa-mir-380-3p ; hsa-mir-365b-3p ; hsa-mir-365a-3p
Nearest miRNA
hsa-mir-12123/Upstream/93676; hsa-mir-10400/Downstream/1066709;
Nearest TSS
ENST00000518652/Upstream/11811; ENST00000518633/Downstream/64819;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24621, chr8-CpG: 145/Downstream/98493
Upstream sequence
TGTGGAGGTAGAGCCAGCCCCTCAtgtctgttttggatgttttgtgtctctccagctacattgtaagttccttgagggcagggccatggcccattgctct
Downstream sequence
gtgaatctcaaatgcccataaaaggtgcccataaaatgttttcttgaacatttgaatgTGCTGTTGTCTGGAAAGGGGTAATATTGTGAGCTGAATCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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