Basic Information
VIS ID
TVIS44016873
Fusion event
HTLV-1-NSMCE2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
126176225/125163983 (Hg38)
End
126176225/125163983 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
NSMCE2
miRNAs that regulate target gene
hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-764 ; hsa-mir-6504-3p ; hsa-mir-3159 ; hsa-mir-552-3p ; hsa-mir-1303 ; hsa-mir-3188 ; hsa-mir-6866-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-12123/Upstream/341925; hsa-mir-10400/Downstream/2631979;
Nearest TSS
ENST00000518652/Upstream/39839; ENST00000521460/Downstream/187433;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/72103, chr8-CpG: 216/Downstream/265246
Upstream sequence
AGGTTTAACCATAAATAGTTCATTGTGATCCAATTTCTATAAAGCTGTTAACAAAGCCCACTTGTAGTATGAATATTAGCTTGGAGTTTGTTTCAAGTAT
Downstream sequence
GTTGGAGGCCTTAGCCCAGGTCTGGATAAGATAATGAATCCACCTCTCTTCTAGCTTCCCCACTTATTTAATATTTGCACAGGGCTTACTTAAGCCAGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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