Basic Information
VIS ID
TVIS44016898
Fusion event
HTLV-1-DGAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145544016/144320353 (Hg38)
End
145544016/144320353 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
DGAT1
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-183-5p ; hsa-mir-4468 ; hsa-mir-6849-3p ; hsa-mir-548q ; hsa-mir-5197-3p ; hsa-mir-2278 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6817-5p ; hsa-mir-4769-3p ; hsa-mir-3065-3p ; hsa-mir-3620-3p ; hsa-mir-6858-3p ; hsa-mir-6871-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-1204/Upstream/3038; hsa-mir-10400/Downstream/73796;
Nearest TSS
ENST00000518652/Upstream/1629; ENST00000644270/Downstream/6314;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/28076, chr8-CpG: 158/Downstream/5968
Upstream sequence
CCCAAGGGGTTGGGGAGAATACACAGTGCTGCCTGGGCTGGACAAGGCCCAACCTGGGCCAGGAATGGGCTGCGTCTCCTGAGTGCTGGGCTGGCGCTGG
Downstream sequence
GCCCACTGTCCTCCTGCCTGGCCAGCTTCTCAGCCACCAGGACTCGTGGGCCTCCACAGCTGGCCACCCCCAGGGAACCTTCTAGGACCATGGGCGGTGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate