Basic Information
VIS ID
TVIS44016899
Fusion event
HTLV-1-PPP1R16A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
145709043/144483660 (Hg38)
End
145709043/144483660 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
PPP1R16A
miRNAs that regulate target gene
hsa-mir-1-3p
Nearest miRNA
hsa-mir-10400/Upstream/21121; hsa-mir-6850/Downstream/308271;
Nearest TSS
ENST00000518652/Upstream/5309; ENST00000533829/Downstream/6370;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/5141, chr8-CpG: 111/Downstream/16417
Nearby gene
FOXH1(-7325) ;
Upstream sequence
cgccacgaccggcttttgtatttttagtagaaatggggttttaccctgttggtcaggctggtctcgaactcttgacctcaggtgatccacccgccttggc
Downstream sequence
ctcccaaagtgctgggattacaggcatgagccactgcgcccggtctctttttttttttgagacagagtcttgctctgttgcccaggctggagagcagtgg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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