Basic Information
VIS ID
TVIS44016911
Fusion event
HTLV-1-GFRA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21587445/21729933 (Hg38)
End
21587445/21729933 (Hg38)
Orient
-
Location type
Intronic
Target gene
GFRA2
Nearest miRNA
hsa-mir-124-1/Upstream/4048276; hsa-mir-10400/Downstream/515033;
Nearest TSS
ENST00000518652/Upstream/431694; ENST00000520754/Downstream/58226;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1425759, chr8-CpG: 24/Downstream/20633
Upstream sequence
AAGGGACCACATCCCGCCCTGACCTGCCTGGAGCTCCTGTTTCTGGGCCTAAGAAGCCCAAATACTAAACCGAACAGCTGGTGGGCCCAAAGGTCTGCTC
Downstream sequence
CCAGACCCAGCAAGCCTGGAATTAGAGAGGCAGAGATCCCACCACACTCTGGGGAATTCAGGGAGGAGGAGGAGGAGCTGCAGGGTGGACCTCGAGGGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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