Basic Information
VIS ID
TVIS44016946
Fusion event
HTLV-1-PRKDC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
48835747/47923187 (Hg38)
End
48835747/47923187 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRKDC
miRNAs that regulate target gene
hsa-mir-101-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-124-1/Upstream/5026912; hsa-mir-10400/Downstream/13791601;
Nearest TSS
ENST00000518652/Upstream/58395; ENST00000520994/Downstream/5982;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/91571, chr8-CpG: 36/Downstream/36711
Upstream sequence
aagtctcactctgtcgcccaggctggagtgcaacggcgtgatctcggctcactgcaacctctgcctcccgggttcaagtggttctctggtctcagcctcc
Downstream sequence
caagtagctgggattacaggtgtgcgccatcatgccaggctaattttttttctttttagtagagacacggtttcaccatgtttgccaggctggtctcaaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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