Basic Information
VIS ID
TVIS44016955
Fusion event
HTLV-1-MRPL15 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
55049341/54136781 (Hg38)
End
55049341/54136781 (Hg38)
Orient
+
Location type
Intronic
Target gene
MRPL15
miRNAs that regulate target gene
hsa-let-7a-5p
Nearest miRNA
hsa-mir-124-1/Upstream/11240506; hsa-mir-10400/Downstream/7578007;
Nearest TSS
ENST00000518652/Upstream/273; ENST00000297316/Downstream/321154;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/1336, chr8-CpG: 123/Downstream/316839
Upstream sequence
TTTTAAAGTACAGGTCCCCAATTTCCATTAAAAAGCACCTAAAAATAGTTTGGTAGAAATTTTGGTGGAAATTGTAAATTCACTTTGAAGCAAACTTTTG
Downstream sequence
CTACTGTTCCCCTGAACCATTTTTTGGTAATGAAATCTTGCCTGGATTATTAAAAGGAAAAGAGGCCCAGACACTGCACTTAGacctgcaaaatggagat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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