Basic Information
VIS ID
TVIS44017009
Fusion event
HTLV-1-TMEM38B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
108473817/105711536 (Hg38)
End
108473817/105711536 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM38B
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-let-7a-1/Upstream/7482319; hsa-mir-12126/Downstream/889392;
Nearest TSS
ENST00000422679/Upstream/5861; ENST00000451560/Downstream/10151;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/16381, chr9-CpG: 55/Downstream/1148607
Upstream sequence
tctcaaaaaaaaagaaaagaaaagaaaaAGGAAAATACAGAAAACCACAAAGCCAAACATAAGACCtaatgaattattataaggtacatccttgtaacca
Downstream sequence
ctacccaaatcaagaaatacaactttgcgcctgggacagttgctcatgcctgtaatcccagcactttgggaggctgaggcatcgcttgagcccaggagtt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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