Basic Information
VIS ID
TVIS44017014
Fusion event
HTLV-1-FRRS1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
111926112/109163832 (Hg38)
End
111926112/109163832 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
FRRS1L
miRNAs that regulate target gene
hsa-mir-1283 ; hsa-mir-665 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-4423-3p ; hsa-mir-329-5p
Nearest miRNA
hsa-let-7a-1/Upstream/117534; hsa-mir-12126/Downstream/347643;
Nearest TSS
ENST00000422679/Upstream/11639; ENST00000465091/Downstream/3101;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/43834, chr9-CpG: 63/Downstream/3085
Upstream sequence
GAAGGGGGTACCCTGCACAGAGGGAACAAGTAGCCTAGTCACTAGAAATGGACAACCTCAAGTGTATTGATAGAATAAGTCAAAGGCATTACCGGCACTT
Downstream sequence
CTTCACTTGCCACGTCCTCCAAGGTcagtcaggttccctccttccttctccactgaatctgtcctaggagagttccacccataacctctcatctcctgaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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