Basic Information
VIS ID
TVIS44017018
Fusion event
HTLV-1-SVEP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
113336173/110573893 (Hg38)
End
113336173/110573893 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
SVEP1
miRNAs that regulate target gene
hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-4753-3p ; hsa-mir-20a-3p ; hsa-mir-130b-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-501-5p ; hsa-mir-6888-5p ; hsa-mir-3156-5p
Nearest miRNA
hsa-let-7a-1/Upstream/1062348; hsa-mir-12126/Downstream/697263;
Nearest TSS
ENST00000422679/Upstream/23839; ENST00000451108/Downstream/5845;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/316876, chr9-CpG: 99/Downstream/5040
Upstream sequence
ACTCACCCAGAACAAACAGCTGAAGAGCTTTTCATTAATTCTGTAAAAGGATTTCATGTAATTAAGTTCAAGGTGCTAAACTTTCCCCCAGGCTATTGAC
Downstream sequence
TGTGTACTAATTACAGAATTCACTGCTTTAGTCCTTGCACTCTTTGAAGAGTGCTAGGGGGTGGTTCTGAAGAGACTATGTCTACACTGCACTTTATCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate