Basic Information
VIS ID
TVIS44017021
Fusion event
HTLV-1-RGS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
GRCh37/hg19
Start
116239053/113476773 (Hg38)
End
116239053/113476773 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9E
Target gene
RGS3
miRNAs that regulate target gene
hsa-mir-126-3p ; hsa-mir-133a-3p ; hsa-mir-26b-5p ; hsa-mir-25-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1544604; hsa-mir-12126/Downstream/732661;
Nearest TSS
ENST00000422679/Upstream/13041; ENST00000466735/Downstream/2098;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/12920, chr9-CpG: 18/Downstream/107347
Upstream sequence
gcttctcacttggccttgcccaagtccctgtcctagccactgggctgtgagccctgtgagggcaggcacctgcccagcctcgtgcagatgcccagcaaat
Downstream sequence
atttgctaaatggaATTAGTGACCATTTGTGTCTGGAGATTTCCTGATCCTGACTTCTGGGCAAAGGGCCACTGTTAGTTAGGTGATAGGTGTTGTGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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