Basic Information
VIS ID
TVIS44017038
Fusion event
HTLV-1-NUP214 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.13
Reference genome
GRCh37/hg19
Start
134073924/131198537 (Hg38)
End
134073924/131198537 (Hg38)
Orient
+
Location type
Exonic
Target gene
NUP214
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-193b-3p ; hsa-mir-331-3p ; hsa-mir-328-3p ; hsa-mir-149-5p ; hsa-mir-15b-5p ; hsa-mir-22-3p ; hsa-mir-20a-5p ; hsa-mir-218-5p ; hsa-mir-6515-3p ; hsa-mir-520f-5p ; hsa-mir-216b-5p ; hsa-mir-618 ; hsa-mir-548c-3p ; hsa-mir-1236-3p ; hsa-mir-6847-3p ; hsa-mir-767-3p ; hsa-mir-133b
Nearest miRNA
hsa-let-7a-1/Upstream/572174; hsa-mir-126/Downstream/1747170;
Nearest TSS
ENST00000422679/Upstream/1199; ENST00000530491/Downstream/23961;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/72618, chr9-CpG: 17/Downstream/62288
Nearest cancer related gene
NUP214(OG, No orient, 0)
Upstream sequence
TCCTGCTGCCAGTTCTAGCTCAGCTTTCAACCAGCTCACCAACAACACAGCCACTGCCCCCTCTGCCACGCCCGTGTTTGGGCAAGTGGCAGCCAGCACC
Downstream sequence
GCACCAAGTCTGTTTGGGCAGCAGACTGGTAGCACAGCCAGCACAGCAGCTGCCACACCACAGGTCAGCAGCTCAGGGTTTAGCAGCCCAGCTTTTGGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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