Basic Information
VIS ID
TVIS44017050
Fusion event
HTLV-1-PNPLA7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
GRCh37/hg19
Start
140359812/137465360 (Hg38)
End
140359812/137465360 (Hg38)
Orient
-
Location type
Intronic
Target gene
PNPLA7
miRNAs that regulate target gene
hsa-mir-2110 ; hsa-mir-3144-5p ; hsa-mir-3150a-3p ; hsa-mir-3189-3p ; hsa-mir-3191-3p ; hsa-mir-4433a-5p ; hsa-mir-450a-2-3p ; hsa-mir-4652-5p ; hsa-mir-5588-3p ; hsa-mir-662 ; hsa-mir-6763-5p ; hsa-mir-6810-5p ; hsa-mir-6857-5p ; hsa-mir-7-5p
Nearest miRNA
hsa-let-7a-1/Upstream/15274; hsa-mir-602/Downstream/373059;
Nearest TSS
ENST00000422679/Upstream/540; ENST00000371443/Downstream/14071;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/2825, chr9-CpG: 20/Downstream/1394
Upstream sequence
AAGCCAGACCACACGCCCACTGTCCCCTCTCCTCAGCATGAGGGGCAGGCACACAGCCCCGGCCTCACCTTGCCCCGGCCAGTTCCCAGGGCCCAGTGAT
Downstream sequence
CCCAGCACGGAAAGAGGACCAGCCCAGAGAGCTCTGGCCATTCCCACACCTGGCCCCCCAGCCCCAGACCCACAGACGGAGGGACAGGGAGAGGGCCACC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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