Basic Information
VIS ID
TVIS44017055
Fusion event
HTLV-1-PSIP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
15486196/15486198 (Hg38)
End
15486196/15486198 (Hg38)
Orient
-
Location type
Intronic
Target gene
PSIP1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-101-2/Upstream/9478294; hsa-let-7a-1/Downstream/3087108;
Nearest TSS
ENST00000422679/Upstream/11997; ENST00000474193/Downstream/24091;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/62996, chr9-CpG: 107/Downstream/23980
Nearest cancer related gene
PSIP1(OG, No orient, 0)
Upstream sequence
AATAAATTATTCCAGGAATGAAAGAAACCTTGTTAAACTAAAAGTTACAAGCACGTTTAACTGAAAGCATTGGGGAAATCTGTTTTGCTCTGTAGAGTTC
Downstream sequence
TGAAATTAAAAACATTGTGTCTCAACATTATAAAGTGAGAAAAATGCATTTCCACTGTCAGATCAAATGTAAGTCATGGTTGCTGGTACACCAGGAAGTC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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