Basic Information
VIS ID
TVIS44017058
Fusion event
HTLV-1-DENND4C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
19318109/19318111 (Hg38)
End
19318109/19318111 (Hg38)
Orient
+
Location type
Intronic
Target gene
DENND4C
miRNAs that regulate target gene
hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-4775 ; hsa-mir-550b-2-5p ; hsa-mir-1227-3p ; hsa-mir-5189-3p ; hsa-mir-4714-3p ; hsa-mir-7849-3p ; hsa-mir-590-3p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-33a-3p ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-129-5p ; hsa-mir-4776-3p ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-302f ; hsa-mir-5692a ; hsa-mir-633 ; hsa-mir-223-5p ; hsa-mir-496 ; hsa-mir-4781-3p ; hsa-mir-1304-3p ; hsa-mir-215-3p ; hsa-mir-3664-5p ; hsa-mir-3672 ; hsa-mir-4639-3p ; hsa-mir-6773-3p ; hsa-mir-6794-3p ; hsa-mir-6864-3p ; hsa-mir-6879-3p ; hsa-mir-8055
Nearest miRNA
hsa-mir-101-2/Upstream/744732; hsa-let-7a-1/Downstream/1093037;
Nearest TSS
ENST00000422679/Upstream/25535; ENST00000602442/Downstream/18293;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/86791, chr9-CpG: 48/Downstream/61685
Upstream sequence
tcctggagcttattaaagttttctctaatgggcgcagtggctcacgcctgtaatcccaacactttgggagactaaggcaggcagatcacctgaggttacg
Downstream sequence
agttcgagaccagcctggccaacatggtgaaaccctgtctctacgaaaaatataaaaattagccaggtgtggtggtgtgtgcctgtaatcccagctattc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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