Basic Information
VIS ID
TVIS44017087
Fusion event
HTLV-1-SMC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
72914388/70299472 (Hg38)
End
72914388/70299472 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMC5
miRNAs that regulate target gene
hsa-mir-377-3p ; hsa-mir-4653-3p ; hsa-mir-216b-3p ; hsa-mir-4459 ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6087 ; hsa-mir-1247-3p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-570-3p ; hsa-mir-28-3p ; hsa-mir-708-3p ; hsa-mir-7844-5p
Nearest miRNA
hsa-mir-101-2/Upstream/29065637; hsa-let-7a-1/Downstream/510503;
Nearest TSS
ENST00000422679/Upstream/17000; ENST00000475540/Downstream/24101;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/40124, chr9-CpG: 161/Downstream/112942
Upstream sequence
GGAAAAAAAAAGCTGTCTTATCGGGCATTCTCCTGAGtcccatagccttctgtccttctccttccatctaaactggttgttcttgaggcctcctgcatgg
Downstream sequence
ttatcatttgtaatttctctcgtgccttttctgtgttataaacctattcctgaattccatgtctcattttcttacatcacgcccttattttgttggagta
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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