Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene877125968749722887708633875920918760239987603761876083548756833687572757875540268755739987557793875607028758065987582999875631608756453487564727875655498757557987576297875616588756232387567400875679498758017187580507875787068757885587603106876032558760330687603455875679518756804987604912
Basic Information
VIS ID
TVIS44017108
Fusion event
HTLV-1-DAPK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
90219827/87604912 (Hg38)
End
90219827/87604912 (Hg38)
Orient
+
Location type
Intronic
Target gene
DAPK1
miRNAs that regulate target gene
hsa-mir-214-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-124-3p ; hsa-mir-218-5p ; hsa-mir-1277-5p ; hsa-mir-448 ; hsa-mir-190a-3p ; hsa-mir-4671-3p ; hsa-mir-5011-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-5580-3p ; hsa-mir-130a-3p ; hsa-mir-376c-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/3635055; hsa-let-7a-1/Downstream/1140924;
Nearest TSS
ENST00000422679/Upstream/105906; ENST00000463069/Downstream/34526;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/106010, chr9-CpG: 24/Downstream/54626
Nearest cancer related gene
DAPK1(TSG, No orient, 0)
Upstream sequence
ATCCCTACCTAATTTGTTACTTTCCACAATTGGAACTTTCCTATTCACAGTTCTCTTGTCCCCCTCTGCACCATGCCACATCCTCACTCAAATCCTGTTT
Downstream sequence
TTTTTATGAACGATAAAGAATCCTCCATCTTCTCTTTTCAGTGGACAGTTTGCGGTTGTGAAGAAATGCCGTGAGAAAAGCACCGGCCTCCAGTATGCCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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