Basic Information
VIS ID
TVIS44017111
Fusion event
HTLV-1-PTPRD integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
8967606/8967606 (Hg38)
End
8967606/8967606 (Hg38)
Orient
-
Location type
Intronic
Target gene
PTPRD
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-1-3p ; hsa-mir-200b-3p ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-374b-3p ; hsa-mir-3924 ; hsa-mir-340-5p ; hsa-mir-4524b-5p ; hsa-mir-4791 ; hsa-mir-4524a-5p ; hsa-mir-3201 ; hsa-mir-891b ; hsa-mir-1246 ; hsa-mir-8076 ; hsa-mir-3163 ; hsa-mir-646 ; hsa-mir-5583-3p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-15a-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-135a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/2959702; hsa-let-7a-1/Downstream/9605700;
Nearest TSS
ENST00000422679/Upstream/31527; ENST00000449531/Downstream/831817;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/108898, chr9-CpG: 76/Downstream/1645029
Nearest cancer related gene
PTPRD(TSG, No orient, 0)
Upstream sequence
catgtcctttgcaacaacatagatgaagctggaggccattatcctaagcgaattaacacaCCAAATCAATCTTGGAGGTCAATAACTAAGAACGTGGTAT
Downstream sequence
CAAAAAACAATAGAAAATTAATGAGTCACTTAGTATATGGTATTGAAAATGATTCATAACATGCAAAAAATAAAACTGAATTCTTACTGAAATATACGTA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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