Basic Information
VIS ID
TVIS44017118
Fusion event
HTLV-1-FANCC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
97868219/95105937 (Hg38)
End
97868219/95105937 (Hg38)
Orient
+
Location type
Intronic
Target gene
FANCC
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-15b-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-5192 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-3613-3p ; hsa-mir-6760-5p ; hsa-mir-7844-5p ; hsa-mir-5007-5p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-587 ; hsa-mir-302c-5p ; hsa-mir-873-5p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-1273f ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6812-3p ; hsa-mir-6733-3p
Nearest miRNA
hsa-let-7a-1/Upstream/19843; hsa-mir-12126/Downstream/2257617;
Nearest TSS
ENST00000422679/Upstream/49667; ENST00000423075/Downstream/7771;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/19694, chr9-CpG: 25/Downstream/186476
Upstream sequence
ttgtgggtacagatcacacggtgcattgcttgtccctctacaggcgtttaggccatctctgcctgctggctgctgagaatagtgctgccctgagcactgg
Downstream sequence
gccagatggccctccagcccctgctttcggctctctgggttatagacctaggagaactgcctgccacatggtaattccaagtttggctgtttgaggaacc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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