Basic Information
VIS ID
TVIS44017120
Fusion event
HTLV-1-ZNF367 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
99166151/96403869 (Hg38)
End
99166151/96403869 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNF367
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-99a-5p ; hsa-mir-4517 ; hsa-mir-1468-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-548aj-5p ; hsa-mir-548aw ; hsa-mir-338-5p ; hsa-mir-3161 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-646 ; hsa-mir-139-5p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-16-5p ; hsa-mir-302c-5p ; hsa-mir-3143 ; hsa-mir-203a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4291 ; hsa-mir-539-5p ; hsa-mir-545-3p ; hsa-mir-1252-3p ; hsa-mir-24-2-5p ; hsa-mir-24-1-5p ; hsa-mir-409-3p ; hsa-mir-4735-3p ; hsa-mir-18a-5p ; hsa-mir-18b-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-4703-3p ; hsa-mir-7852-3p ; hsa-mir-3668
Nearest miRNA
hsa-let-7a-1/Upstream/1317775; hsa-mir-12126/Downstream/959685;
Nearest TSS
ENST00000422679/Upstream/20159; ENST00000375251/Downstream/14460;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/20066, chr9-CpG: 228/Downstream/13328
Upstream sequence
gtctctttaacaaatggttctgggataactggatttccatatacaaaaggataaagttagacccctaccttacactatatacaaaaactaactcaaaatg
Downstream sequence
taccacagagctaaatataagaacgaaaactatagagctcttagctggacacggtagcccatgcctgtaatcccagcactttgggaggccaaggtgggtg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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