Basic Information
VIS ID
TVIS44017123
Fusion event
HTLV-1-MFSD14C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
99717424/96955142 (Hg38)
End
99717424/96955142 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
MFSD14C
miRNAs that regulate target gene
hsa-mir-887-3p ; hsa-mir-4294 ; hsa-mir-924 ; hsa-mir-4635 ; hsa-mir-1273g-3p ; hsa-mir-550b-2-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-7703 ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-542-3p ; hsa-mir-661 ; hsa-mir-6743-3p ; hsa-mir-6776-5p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-6742-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-8057 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-1304-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-let-7a-1/Upstream/1869048; hsa-mir-12126/Downstream/408412;
Nearest TSS
ENST00000422679/Upstream/5557; ENST00000420204/Downstream/17799;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/29837, chr9-CpG: 104/Downstream/57674
Upstream sequence
CAAAGACCTAGTGCCAGGACGAGTGTCCCTGGTGATGGAACGTTCAGAGGAGCTCAACAACGACCTAAACCCCTTTACTCCTCTTACAAGGTATCCGGAT
Downstream sequence
TCCTGATTATGCCTTTATGCAAGACTTGGCCAAGATGTATGAGCATCCTCTTGCTCTCACTAGTGCCAACCTCAGCTCCCAGGACAGTTCTCTGAATGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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