Basic Information
VIS ID
TVIS44017127
Fusion event
HTLV-1-LZTS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102761962/101002205 (Hg38)
End
102761962/101002205 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
LZTS2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-107/Upstream/27121; hsa-mir-1307/Downstream/599212;
Nearest TSS
ENST00000439456/Upstream/2352; ENST00000489434/Downstream/28563;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2164, chr10-CpG: 22/Downstream/3243
Upstream sequence
ATGAGGCCACCTGGCTGAGAGGACCAGGGACCTGTGCTTCAAGCTGGTAGAGAAGGCCCCTCCCTCACCTGAGTCCTGGCCTCTGTGGAGGATGCAGGAT
Downstream sequence
TGGGCTTGGGCCTGGGTCTTTGCTGCCAGGTGGCCCTGCGGTAATCATCCAGGCCTCCCATGCCTCTCAGCATCTCTGCTGAGTGAATTCACTCCTCAGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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