Basic Information
VIS ID
TVIS44017129
Fusion event
HTLV-1-NEURL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
105337729/103577972 (Hg38)
End
105337729/103577972 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
NEURL1
miRNAs that regulate target gene
hsa-mir-331-3p ; hsa-mir-629-3p ; hsa-mir-4713-5p ; hsa-mir-5088-3p ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-3064-5p ; hsa-mir-3194-5p ; hsa-mir-328-5p ; hsa-mir-3652 ; hsa-mir-3943 ; hsa-mir-4430 ; hsa-mir-4505 ; hsa-mir-4676-5p ; hsa-mir-4731-5p ; hsa-mir-575 ; hsa-mir-5787 ; hsa-mir-637 ; hsa-mir-6504-5p ; hsa-mir-6795-5p ; hsa-mir-6842-3p ; hsa-mir-6858-3p ; hsa-mir-6885-5p ; hsa-mir-6887-5p ; hsa-mir-7109-5p
Nearest miRNA
hsa-mir-107/Upstream/183571; hsa-mir-202/Downstream/470117;
Nearest TSS
ENST00000439456/Upstream/6295; ENST00000609691/Downstream/30647;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/22485, chr10-CpG: 138/Downstream/6444
Nearest cancer related gene
NEURL1(TSG, No orient, 0)
Upstream sequence
CACAATGAATATATAtcaagttgaaccatatgtaatcaccagtattggactgtttttaacttacaagaaaggcaatctcatgtTTGCCCCTAGCATCTCT
Downstream sequence
TGGGCCCAAGAGATTGTACTGGGGCCTTGGAGAGAGTGGTGGGGCTCAGGGTGGGGTGTATGTGGAGGGAGGAGCTCGggccttgcagtattggggacaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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