Basic Information
VIS ID
TVIS44017134
Fusion event
HTLV-1-DUSP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
112263366/110503608 (Hg38)
End
112263366/110503608 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
DUSP5
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-335-5p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-16-1-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-203a-3p ; hsa-mir-222-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-627-5p ; hsa-mir-924 ; hsa-mir-3912-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-302a-5p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-107/Upstream/6235203; hsa-mir-202/Downstream/394482;
Nearest TSS
ENST00000439456/Upstream/861; ENST00000462899/Downstream/64083;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/4682, chr10-CpG: 27/Downstream/26581
Nearest cancer related gene
DUSP5(TSG, No orient, 0)
Upstream sequence
TCTAAAAATGAGTGCTTTGTGATAACTCATTAAAGGGAAAAATAAAGTGGAAGGGGGTTACGTAGCACCATCCAGGAAGATGAAAAAGCAGGTGagaatc
Downstream sequence
caaatctggcagaagccagagatcaaaacctaaccattttacggaagggaaaagaagtgttctgtgacaagtgagatgattgattttgcagagtcctaca
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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