Basic Information
VIS ID
TVIS44017137
Fusion event
HTLV-1-CELF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
11185067/11143104 (Hg38)
End
11185067/11143104 (Hg38)
Orient
+
Location type
Intronic
Target gene
CELF2
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-375 ; hsa-mir-324-5p ; hsa-let-7e-5p ; hsa-mir-95-3p ; hsa-mir-4717-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-192-3p ; hsa-mir-124-5p ; hsa-mir-4275 ; hsa-mir-203a-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-642a-5p ; hsa-mir-329-5p ; hsa-mir-4748 ; hsa-mir-4464
Nearest miRNA
hsa-mir-3155a/Upstream/4990827; hsa-mir-107/Downstream/987656;
Nearest TSS
ENST00000439456/Upstream/37600; ENST00000354897/Downstream/21926;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/124310, chr10-CpG: 32/Downstream/22516
Upstream sequence
TGGGGGGACTCACTCCCCTTGTGATTCTTCTGTCCTCCCTCCACTGGGGGGACTCACTCCCCTCGTGATTCTTCTGTCCTCCCTCCACTGGGGAATCTCG
Downstream sequence
CTCCCCTCGTGCTTCTTCCTCTCCTCCTGTTGTCCTCTTTTTCCTTTGTGTGCCTGTAATGGACACTTTTCCATTCCATATCTCTTGGGTTTTGGAGATG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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