Basic Information
VIS ID
TVIS44017138
Fusion event
HTLV-1-VTI1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
114302155/112542396 (Hg38)
End
114302155/112542396 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
VTI1A
miRNAs that regulate target gene
hsa-mir-18a-3p ; hsa-mir-18b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-6891-3p ; hsa-mir-452-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-302a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-205-5p ; hsa-mir-6793-3p ; hsa-mir-532-5p ; hsa-mir-141-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-107/Upstream/242706; hsa-mir-202/Downstream/91774;
Nearest TSS
ENST00000439456/Upstream/95037; ENST00000346198/Downstream/135423;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/94834, chr10-CpG: 34/Downstream/407494
Upstream sequence
ACCGGTACTGTAGATGGGCCCCCGTGCACCTGGCAGTGCATCTCTGGAACTGTGAGAGTTTGTCTACACTCAGCAGCCTCACATCCTTGAATCACGATCT
Downstream sequence
GTACCACTTGATGACCTTGCTCCCCCATCCCTCACCAGCAAGCCTTACAAGTTGTCACCCCTTCTCTCAGTAGTCACTGCAGGCCACCTCGCCCTGACTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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