Basic Information
VIS ID
TVIS44017139
Fusion event
HTLV-1-PLEKHS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
115517078/113757319 (Hg38)
End
115517078/113757319 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PLEKHS1
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-6832-5p ; hsa-mir-411-5p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-744-3p ; hsa-mir-8057 ; hsa-mir-106a-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-3622b-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5197-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6780a-3p ; hsa-mir-6881-3p ; hsa-mir-7111-3p ; hsa-mir-877-3p
Nearest miRNA
hsa-mir-107/Upstream/1123065; hsa-mir-202/Downstream/20674;
Nearest TSS
ENST00000439456/Upstream/5865; ENST00000369310/Downstream/7500;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/76882, chr10-CpG: 66/Downstream/97295
Upstream sequence
CCATAtttttaatagctttattgtagtttattgtaattggcatacaataagctattatatatctaaagtgtacaatttgatagaagttttgatatGAAAC
Downstream sequence
ATATAcaagcacacctcagagatatttcaagtttgtttccatgccaatacaaccaagcaaatatcacaataaagctagtcacatgaatttattggattcc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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