Basic Information
VIS ID
TVIS44017141
Fusion event
HTLV-1-SFXN4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
GRCh37/hg19
Start
120906448/119146936 (Hg38)
End
120906448/119146936 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
SFXN4
miRNAs that regulate target gene
hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-513a-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-4524a-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-4524b-3p ; hsa-mir-144-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p
Nearest miRNA
hsa-mir-107/Upstream/1979162; hsa-mir-202/Downstream/231036;
Nearest TSS
ENST00000439456/Upstream/10419; ENST00000392870/Downstream/8187;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/42044, chr10-CpG: 85/Downstream/18337
Upstream sequence
ggattacaggcgtgagccaccgcaccATCCCATCCCTCCTTCTTGGAAATGTGCTCCATGTGTGGTCCTAGCAGGCGATTCCCAGCCTCGCCACACTGGT
Downstream sequence
GGGGGGGATGTGCACCCCAGGCATGCGACCTAACTCAGGCCCACAGAATCCTTCCCCAGGAGTCTGCCCTGAGGGGAAGACATTCCTGCCTCCCCTGGGG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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