Basic Information
VIS ID
TVIS44017142
Fusion event
HTLV-1-UPF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p14
Reference genome
GRCh37/hg19
Start
12081260/12039261 (Hg38)
End
12081260/12039261 (Hg38)
Orient
-
Location type
Intronic
Target gene
UPF2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-3155a/Upstream/5886984; hsa-mir-107/Downstream/91499;
Nearest TSS
ENST00000439456/Upstream/3364; ENST00000437298/Downstream/3573;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/144200, chr10-CpG: 91/Downstream/2976
Upstream sequence
tgggtattattttccctattttataaatgagtaaactgagacttgaccaagtaacttgaccaaggcctgcacagctggtgacagaatgggaatctgaacc
Downstream sequence
caTTCTCTGAACCAAAGAATCCTAAGAGTACCAAATTGTGAGATGGGAGACATGCTGGTAAATACTGACTATAGCAACCCACAGAATTATGAATCTCAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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